...молодость - это надолго

  • Увеличить размер
  • Размер по умолчанию
  • Уменьшить размер


Khokhlov A.N.
Evolutionary Cytogerontology Sector, School of Biology, Lomonosov Moscow State University, Moscow, Russia; Данный адрес e-mail защищен от спам-ботов, Вам необходимо включить Javascript для его просмотра.

The considerably increased recently interest in experimental-gerontological research has led to a paradoxical situation: although more and more papers in the field appear, only a small part of them is really devoted to the study of mechanisms of aging.  In my opinion, it is determined, inter alia, by the following circumstances: 1) As a rule, the classical definition of aging as a set of age-related changes, leading to an increase in the probability of death of organism is ignored. 2) The focus is placed upon achieving a longer life span, although it often has nothing to do with the impact on the aging process (in particular, quite successfully, you can increase life span of non-aging organisms; at the same time, the presence of aging does not necessarily indicate a low longevity). 3) Animals with certain abnormalities (like genetic disorders), increasing the probability of their death, are used as control, so any remedy against these pathologies lead to prolongation of life. 4) Too much importance is attached to an increase in average life span, which is largely determined by factors in no way related to aging. 5) Increasingly, gerontological experiments are conducted on model systems that allow obtaining only indirect information about the mechanisms of aging, the interpretation of which depends strongly on the fundamental concept to which the specific researchers adhere. Unfortunately, the above also applies to cytogerontological studies that became extremely popular in recent decades. In particular, many of the conclusions reached earlier on the basis of the results of experiments conducted on Hayflick's model (aging in vitro), were subsequently found to be wrong. In addition, our cytogerontological studies of various anti-aging factors with the help of the "stationary phase aging" model, the cell kinetics model and assessment of colony-forming ability, have shown that in very many cases the factors studied have no beneficial effect on the viability of cultured cells, although they prolong life in experimental animals and increase the well-being of humans. This allowed us to assume that, in many cases, the anti-aging agent action appears only at the organism level, and is not limited to just improving the viability of some of its constituent cells.



Какова роль низкомолекулярных (небелковых) антиоксидантов в организме?
Сейчас на сайте находятся:
 15 гостей 

Самое популярное

ВАЛЕОЦЕНТР имени Н.А. Бобрышева ГЕНЕТИЧЕСКАЯ И РЕГЕНЕРАТИВНАЯ МЕДИЦИНА: ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ Применение омега-3 полиненасыщенных жирных кислот в медицине V НАЦИОНАЛЬНЫЙ КОНГРЕСС ГЕРОНТОЛОГОВ И ГЕРИАТРОВ УКРАИНЫ - ПРОГРАММА Омега-3-ненасыщенные жирные кислоты Онтогенетические часы. Гипотеза Элевационная теория старения Менопауза та її наслідки Проблемы гипобиоза и продления жизни Новые технологии в регенеративной медицине: мировой опыт клинического применения стволовых клеток список участников октябрьского конгресса Жанна Луиза Кальман Основные теории старения Институт геронтологии НАМНУ Теории старения Конференция им.В.В.Фролькиса Препараты против старения Болезнь Альцгеймера Болезнь Паркинсона Онкопатология Возрастзависимая патология Остеопороз Конференции по старению и омоложению Ресвератрол Semagacestat Омега-3-ненасыщенные жирные кислоты Способы омоложения и достижения долголетия Методы исследований в геронтологии Жанна Луиза Кальман Функциональные диеты для омоложения

Последние публикации

Введите логин для входа